CAR T-cell therapy: response and resistance


Nature Reviews Immunology
Jan 10, 2019

This review article by Mackall and Brown highlights key papers published in 2018 that advance our understanding of resistance to chimeric antigen receptor (CAR) T cell immunotherapy for leukaemia and lymphoma and in so doing reveal barriers that must be addressed to increase efficacy of this novel class of therapeutics for B cell malignancies and expand their reach to solid tumours.

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