Circulation
Vol 135, No 11, Mar 14, 2017

Coronary atherosclerosis: one disease or many? One potential paradigm for precision medicine is that additional phenotyping might lead to the identification of a distinct driver (depicted by various colors in this schematic) in each individual. Alternatively, the manifestation of coronary artery disease in each individual may relate to a quantitative blend of such causal factors. Although not mutually exclusive, this dichotomy may help to frame expectations for the All of Us Research Program and other similar precision medicine biobanks. Amit V. Khera, MD

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