Nature Medicine, May 2018
Volume 24, Issue 5

Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report that CAR T cells targeting the disialoganglioside GD2 are capable of killing DMG cells in preclinical models, offering hope for clinical translation of this immunotherapy. The cover depicts a tiger attacking hyenas, which do not naturally coexist in the same geographic region, to represent an exogenously introduced CAR T cell attacking glioma cells.

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